CSR activity report│Fighting Against COVID-19

Supporting vaccine development and manufacturing with advanced technology and production control capabilities

Progress is being made worldwide to develop and widely deploy COVID-19 vaccines. Expanding the availability of highly effective vaccines is expected to prevent the spread and reduce the severity of COVID-19, resulting in fewer restrictions on activities and reducing social risks such as the growing strain on healthcare systems. The Fujifilm Group is dedicating its talents, resources and technologies to manufacturing drug substance for vaccine candidates to ensure a steady supply of high-quality vaccines as quickly as possible.

In July 2020, FUJIFILM Diosynth Biotechnologies (FDB), a biopharmaceutical contract development and manufacturing organization (CDMO), was tapped by U.S. biotechnology company, Novavax, Inc., to manufacture the antigen of its NVX-CoV2373 COVID-19 recombinant protein vaccine candidate. The antigen in a vaccine is one of the main components that generate an immune response.

In the same month, FDB began production for Novavax’s vaccine candidate at its facility in North Carolina, and its Texas facility began production in December 2020. As part of the U.S. government’s Operation Warp Speed, a public-private initiative for the accelerated development and distribution of COVID-19 vaccines and therapeutic drugs, an agreement was signed to secure a portion of the manufacturing capacity through the end of 2021 at the Texas facility for the Biomedical Advanced Research and Development Authority, an office of the U.S. Department of Health and Human Services. In August 2020, FDB’s facility in the U.K. was tapped to manufacture for Novavax’s vaccine candidate, with production initiating in February 2021.

In Japan, Fujifilm signed an agreement with biotechnology company VLP Therapeutics Japan (VLP Therapeutics) in October 2020 for the manufacture of a COVID-19 vaccine formulation. This COVID-19 vaccine is a lipid nanoparticle formulation containing self-amplifying RNA (a replicon)*1 as the active ingredient. Going forward, the Fujifilm Group will utilize its manufacturing equipment and infrastructure, including the lipid nanoparticle manufacturing equipment at FUJIFILM Toyama Chemical’s 701 Facility, to take on everything from process development to manufacturing for clinical trials of VLP Therapeutics’ COVID-19 vaccine formulations.

Fujifilm Group COVID-19 vaccine development and manufacturing support activities*2

  • *1 RNA (ribonucleic acid) is a biopolymer composed of a base, sugar and phosphoric acid. It is a type of nucleic acid that governs genetic information. RNA that was added with a function that causes temporary RNA proliferation in vivo after administration is called self-amplifying RNA, or replicon.
  • *2 As of June 2021

FUJIFILM Diosynth Biotechnologies plays core role in supporting vaccine manufacturing

FUJIFILM Diosynth Biotechnologies (FDB) has facilities in the U.K., the U.S., and Denmark and provides the contract development and manufacture of various types of biopharmaceuticals including antibody drugs, recombinant protein, gene therapy drugs and vaccines. Biopharmaceuticals are proteins produced in expression systems composed of living organisms such as animal and insect cells as well as microbial systems such as E. coli, to name a few. As an industry leader with many decades of experience, FDB provides comprehensive services including the development of cell lines, process development, clinical and commercial production of biologics, vaccines and viral vectors.

Fujifilm has a legacy of advanced production technology, cultivated in the photographic film field, including technology for maintaining certain conditions during manufacturing and advanced quality control. Application of Fujifilm’s technology to expression technology at FDB has made it possible to increase expression titers and maximize production volumes.

Leveraging these strengths, FDB supports the manufacturing of COVID-19 vaccines and therapeutic candidates thus contributing to the fight against COVID-19.

FDB cellular cultivation equipment offers high productivity

Mobile clean rooms enable a safer and more flexible production system


  • * This page has the same contents as Sustainability Report 2021.